NANP Board Practice Exam

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Which of the following foods has been found to slow down the p450 enzyme detoxification process?

  1. Blueberries

  2. Grapefruit

  3. Oranges

  4. Spinach

The correct answer is: Blueberries

Grapefruit has been found to slow down the P450 enzyme detoxification process. This is primarily due to compounds in grapefruit, particularly furanocoumarins, which can inhibit certain cytochrome P450 enzymes, particularly CYP3A4. This inhibition can lead to increased levels of certain medications in the bloodstream, as the liver's ability to metabolize these substances is diminished. While blueberries, oranges, and spinach are all nutritious and have health benefits, they do not have the same documented effect on the P450 enzyme system as grapefruit. Therefore, grapefruit is recognized for its significant interaction with the detoxification processes in the body.

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