NANP Board Practice Exam

What roles do EPA and DHA play in inflammatory related conditions?

1. They suppress prostacyclin synthesis

2. They increase pro-inflammatory eicosanoid synthesis

3. They convert cis fatty acids to trans fatty acids

4. They switch omega 3 to omega 6 fatty acids

The correct answer is: They suppress prostacyclin synthesis

The role of EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid) in inflammatory-related conditions primarily revolves around their beneficial effects on inflammation and their interaction with eicosanoids, which are signaling molecules involved in the inflammatory response. The correct answer highlights that EPA and DHA can suppress prostacyclin synthesis. Prostacyclin is a type of eicosanoid that promotes inflammation and plays a role in vasodilation and platelet aggregation. By influencing the production of prostacyclin and other inflammatory markers, EPA and DHA help to mitigate inflammatory responses, thereby contributing to a reduction in inflammation and potential benefits in various inflammatory conditions. This effect supports the therapeutic use of omega-3 fatty acids in managing inflammatory diseases, demonstrating their capacity to modify the inflammatory pathways and promote a healthier inflammatory balance within the body.